Details

Autor(en) / Beteiligte

• Caubet, Jean-Christoph, MD
• Nowak-Węgrzyn, Anna, MD
• Moshier, Erin, MS
• Godbold, James, PhD
• Wang, Julie, MD
• Sampson, Hugh A., MD

Titel

Utility of casein-specific IgE levels in predicting reactivity to baked milk

Ist Teil von

• Journal of allergy and clinical immunology, 2013-01, Vol.131 (1), p.222-224.e4

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Again, the AUCs for specific IgE levels to casein were greater than the AUCs for specific IgE levels to CM, although the difference was not statistically significant in the first cohort of patients (Fig 1, B). [...]we found very similar values for the positive and negative decision points (ie, 21.4 and 1.0 kUA/L in the first cohort and 20.2 and 0.7 kUA/L in the second cohort, respectively; see Table E2).\n of patients (%) 23 (23.7) 66 (68.0) 8 (8.3)  38 (29.7) 83 (64.8) 7 (5.5)  Age (y)         Median 7.3 6.5 5.8 .55 8.0 7.5 5.9 .1 Range 3.4-14.9 2.1-17.3 2.6-15.0  4.4-10.9 4.0-11.0 4.1-10.9  Sex, no. (%)         Male 14 (60.9) 43 (65.2) 4 (50) .83 27 (71.1) 59 (71.1) 4 (57.1) .74 Female 9 (39.1) 23 (34.8) 4 (50)  11 (28.9) 24 (28.9) 3 (42.9)  Specific IgE (kUA/L)         CM         Median 11.6 2.5 0.9 .00 11.9 4.0 0.7 .00 Range 0.7-101 0.2-79.1 0.2-6.1  0.8-50.5 0.2-42.3 0.2-4.8  Casein         Median 13.9 1.4 1.5 .00 12.2 2.3 0.4 .00 Range 0.7-101 0.2-79.6 0.5-3.7  0.5-67.0 0.2-30.5 0.2-2.0  β-lactoglobulin         Median 4.6 0.5 0.2 .00 2.0 0.6 0.2 .00 Range 0.2-101 0.2-13.8 0.2-2.3  0.2-15.4 0.2-19.8 0.2-7.8  Specific IgG4 (mgA/L)         Casein         Median 1.5 0.6 1.4 .11 1.2 0.8 0.3 .05 Range 0.0-6.7 0.0-23.8 0.2-31  0.1-10.3 0.0-13.1 0.1-1.9  β-lactoglobulin         Median 0.6 0.4 1.3 .15 0.4 0.4 0.1 .72 Range 0.0-8.4 0.0-31 0.1-31  0.0-2.3 0.0-3.9 0.0-2.4  IgE/IgG4 ratio         Casein         Median 10.6 2.5 1.34 .00 6.0 3.0 1.6 .00 Range 1.9-69.3 0-868 0.1-3.7  0.2-109.8 0.1-63.7 0.1-5.0  β-lactoglobulin         Median 6.3 2.4 0.1 .02 3.9 1.9 3.5 .01 Range 0.11-54.7 0-238 0.1-2.4  0.2-81.1 0.1-80.5 0.1-13.7  Table E1 Study participants' characteristics Diagnostic test First cohort (n = 97) Second cohort (n = 128) Specific IgE to CM Specific IgE to casein Specific IgE to β-lactoglobulin Specific IgE to CM Specific IgE to casein Specific IgE to β-lactoglobulin AUCs 80.8% 84.1% 79.5% 73.7% 77.6% 67.8% Optimal cutoff point[low *] 4.7 4.9 2.4 10.1 10.7 0.5 Sensitivity, specificity 73.9%, 77.0% 78.3%, 82.4% 65.2%, 86.5% 65.8%, 81.1% 60.5%, 87.8% 81.6%, 52.2% PPV, NPV 50.0%, 90.5% 58.1%, 92.4% 60.0%, 88.9% 59.5%, 84.9% 67.7%, 84.0% 41.9%, 87.0% Positive decision point[dagger] 28.4 21.4 6.1 25.3 20.2 7.9 Sensitivity, specificity 34.8%, 96.0% 39.1%, 96.0% 43.5%, 96.0% 21.1%, 95.6% 23.7%, 95.6% 10.5%, 95.6% PPV, NPV 72.7%, 82.6% 75.0%, 83.5% 76.9%, 84.5% 66.7%, 74.1% 69.2%, 74.8% 50.0%, 71.7% Negative decision point[double dagger] 0.8 1.0 ND 1.21 0.7 ND Sensitivity, specificity 95.7%, 23.0% 95.7%, 44.6%  97.4%, 20.0% 97.4%, 21.1%  PPV, NPV 27.9%, 94.4% 34.9%, 97.1%  33.9%, 94.7% 34.3%, 95.0%  Table E2 Characteristics of diagnostic tests for determination of clinical reactivity to baked milk ND, Not determined because the highest sensitivity is less than 95%; NPV, negative predictive value; PPV, positive predictive value.