Details

Autor(en) / Beteiligte

• Gershengorn, Marvin C
• Neumann, Susanne

Titel

Update in TSH Receptor Agonists and Antagonists

Ist Teil von

• The journal of clinical endocrinology and metabolism, 2012-12, Vol.97 (12), p.4287-4292

Ort / Verlag

Bethesda, MD: Endocrine Society

Erscheinungsjahr

2012

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The physiological role of the TSH receptor (TSHR) as a major regulator of thyroid function is well understood, but TSHRs are also expressed in multiple normal extrathyroidal tissues, and the physiological roles of TSHRs in these tissues are unclear. Moreover, TSHRs play a major role in several pathological conditions including hyperthyroidism, hypothyroidism, and thyroid tumors. Small molecule, “drug-like” TSHR agonists, neutral antagonists, and inverse agonists may be useful as probes of TSHR function in extrathyroidal tissues and as leads to develop drugs for several diseases of the thyroid. In this Update, we review the most recent findings regarding the development and use of these small molecule TSHR ligands.