The Journal of biological chemistry, 2012-11, Vol.287 (49), p.40875-40883
2012
Details
- Autor(en) / Beteiligte
- Titel
- The Restriction Factors of Human Immunodeficiency Virus
- Ist Teil von
- The Journal of biological chemistry, 2012-11, Vol.287 (49), p.40875-40883
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Cellular proteins called “restriction factors” can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination by promoting APOBEC3 protein degradation; how the viral Vpu, Env, and Nef proteins facilitate internalization and degradation of the virus-tethering protein BST-2/tetherin; and how the viral Vpx protein prevents the premature termination of reverse transcription by degrading the dNTPase SAMHD1. These HIV restriction and counter-restriction mechanisms suggest strategies for new therapeutic interventions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9258eISSN: 1083-351XDOI: 10.1074/jbc.R112.416925Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3510791
- Format
- –
- Schlagworte
- Animals, Antigens, CD - metabolism, APOBEC Deaminases, Cytidine Deaminase, Cytosine Deaminase - metabolism, DNA, Complementary - metabolism, Gene Expression Regulation, Viral, Genome, Viral, GPI-Linked Proteins - metabolism, HIV-1 - metabolism, Host Defense, Host-Pathogen Interactions, Human Immunodeficiency Virus, Humans, Immunity, Innate, Innate Immunity, Macaca, Minireviews, Models, Biological, Monomeric GTP-Binding Proteins - chemistry, Restriction Factors, Reverse Transcription, SAM Domain and HD Domain-Containing Protein 1, T-Lymphocytes - virology, Viral Proteins - metabolism, Virus Replication