Science (American Association for the Advancement of Science), 2010-03, Vol.327 (5973), p.1644-1648
2010
Details
- Autor(en) / Beteiligte
- Titel
- Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae
- Ist Teil von
- Science (American Association for the Advancement of Science), 2010-03, Vol.327 (5973), p.1644-1648
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Extracellular matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system. We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors. This network protects the microbiota by preventing activation of epithelial immunity. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Disruption of this barrier results in strong and effective pathogen-specific immune responses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1184008Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3510679
- Format
- –
- Schlagworte
- Activation, Animals, Anopheles - enzymology, Anopheles - immunology, Anopheles - microbiology, Anopheles - parasitology, Anopheles gambiae, Anti-Bacterial Agents - pharmacology, Bacteria, Bacteria - immunology, Bacterial Physiological Phenomena, Biochemistry, Biochemistry. Physiology. Immunology, Biological and medical sciences, Blood, Cellular biology, Covalent bonds, Digestive system, Digestive System - enzymology, Digestive System - immunology, Digestive System - microbiology, Digestive System - parasitology, Enzyme Induction, Epithelial cells, Epithelial Cells - immunology, Epithelial Cells - microbiology, Epithelial Cells - parasitology, Extracellular Matrix - metabolism, Female, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Immune system, Immunity, Infections, Insect Proteins - metabolism, Insecta, Invertebrates, Malaria, Matrices, Medically important nuisances and vectors, pests of stored products and materials: population survey and control, Messenger RNA, Microorganisms, Midgut, Models, Biological, Mosquitoes, Mosquitos, NADPH Oxidases - genetics, NADPH Oxidases - metabolism, Networks, Nitric Oxide Synthase - biosynthesis, Oxidase, Oxidases, Parasites, Permeability, Peroxidase, Peroxidase - genetics, Peroxidase - metabolism, Physiology. Development, Plasmodium berghei - immunology, Plasmodium berghei - physiology, Plasmodium falciparum - immunology, Plasmodium falciparum - physiology, RNA Interference, Tyrosine - analogs & derivatives, Tyrosine - metabolism, Vectors. Intermediate hosts