Details

Autor(en) / Beteiligte

• Agus, Michael S.D
• Steil, Garry M
• Wypij, David
• Costello, John M
• Laussen, Peter C
• Langer, Monica
• Alexander, Jamin L
• Scoppettuolo, Lisa A
• Pigula, Frank A
• Charpie, John R
• Ohye, Richard G
• Gaies, Michael G

Titel

Tight Glycemic Control versus Standard Care after Pediatric Cardiac Surgery

Ist Teil von

• The New England journal of medicine, 2012-09, Vol.367 (13), p.1208-1219

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• This trial tested the hypothesis that tight glycemic control reduces morbidity after pediatric cardiac surgery. Results indicated that this therapy, as compared with standard care, does not significantly change infection rate, mortality, length of stay, or organ failure. Congenital heart defects are the most common birth defects, with approximately 20,000 pediatric cardiothoracic surgical procedures performed each year in the United States. 1 , 2 Postoperative morbidity and mortality among infants and young children remain relatively high 3 ; thus, identification of modifiable risk factors during postoperative critical care is important for continued improvement in outcomes. Tight glycemic control has emerged as a potential approach to reduce morbidity in adult cardiac medical 4 , 5 and surgical 6 , 7 populations, but it has not proved to be generalizable to all critical care patients. 8 – 11 The incidence of hyperglycemia (blood glucose level >126 mg per deciliter . . .