Details

Autor(en) / Beteiligte

• Dondorp, Arjen M
• Nosten, François
• Yi, Poravuth
• Das, Debashish
• Phyo, Aung Phae
• Tarning, Joel
• Lwin, Khin Maung
• Ariey, Frederic
• Hanpithakpong, Warunee
• Lee, Sue J
• Ringwald, Pascal
• Silamut, Kamolrat
• Imwong, Mallika
• Chotivanich, Kesinee
• Lim, Pharath
• Herdman, Trent
• An, Sen Sam
• Yeung, Shunmay
• Singhasivanon, Pratap
• Day, Nicholas P.J
• Lindegardh, Niklas
• Socheat, Duong
• White, Nicholas J

Titel

Artemisinin Resistance in Plasmodium falciparum Malaria

Ist Teil von

• The New England journal of medicine, 2009-07, Vol.361 (5), p.455-467

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2009

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Artemisinin therapy is a first-line approach to malaria treatment in many parts of the world. Resistance to this class of agents is an emerging threat to malaria treatment and control. In two studies conducted in Thailand and Cambodia, P. falciparum was found to have reduced in vivo susceptibility to artesunate, characterized by slow parasite clearance. In two studies conducted in Thailand and Cambodia, P. falciparum was found to have reduced in vivo susceptibility to artesunate, characterized by slow parasite clearance. Artemisinins are established antimalarial agents with an excellent safety profile. 1 Artemisinin-based combination therapies are now recommended by the World Health Organization (WHO) as first-line treatment of uncomplicated falciparum malaria in all areas in which malaria is endemic. 2 Replacing ineffective, failing treatments (chloroquine and sulfadoxine–pyrimethamine) with artemisinin-based combination therapies has reduced the morbidity and mortality associated with malaria. 3 – 5 Parenteral artesunate is replacing quinine for the treatment of severe malaria. 6 Recently, there have been signs that the efficacy of artemisinin-based combination therapy and artesunate monotherapy have declined in western Cambodia. 7 – 10 Artemisinin resistance would be disastrous for global malaria control. To . . .