Details

Autor(en) / Beteiligte

• Cheung, Chung Yan
• Chan, Eric Y.
• Krasnoselsky, Alexei
• Purdy, David
• Navare, Arti T.
• Bryan, Janine T.
• Leung, Carolina K. L.
• Hui, Kenrie P. Y.
• Peiris, Joseph Sriyal Malik
• Katze, Michael G.

Titel

H5N1 Virus Causes Significant Perturbations in Host Proteome Very Early in Influenza Virus-Infected Primary Human Monocyte-Derived Macrophages

Ist Teil von

• The Journal of infectious diseases, 2012-09, Vol.206 (5), p.640-645

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2012

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• H5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection.