Neuroscience, 2012-12, Vol.226, p.270-281
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Immunological regulation of neurogenic niches in the adult brain
- Ist Teil von
- Neuroscience, 2012-12, Vol.226, p.270-281
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Graphical abstract Highlights ► Proinflammatory cytokines are involved in the pathogenesis of neurological disorders. ► Cytokines and immune mediators regulate neurogenic niches in the adult brain. ► Neuroinflammation can limit the therapeutic use of grafted neural stem cells (NSCs). ► However, neuroinflammation can also promote the regenerative potential of NSCs. ► Stem-cell-based therapies should involve the regulation of immune system mediators.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2012.08.053Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3490038
- Format
- –
- Schlagworte
- Animals, Biochemistry and metabolism, Biological and medical sciences, Brain - cytology, Brain - immunology, Central nervous system, Chemokines - physiology, cytokine, Cytokines - physiology, Fundamental and applied biological sciences. Psychology, Humans, inflammation, interleukin, microglia, neural stem cells, Neural Stem Cells - physiology, Neurodegenerative Diseases - physiopathology, Neurogenesis - immunology, Neurogenesis - physiology, Neurology, subventricular zone, Vertebrates: nervous system and sense organs