Details

Autor(en) / Beteiligte

• Kean, L. S.
• Singh, K.
• Blazar, B. R.
• Larsen, C. P.

Titel

Nonhuman Primate Transplant Models Finally Evolve: Detailed Immunogenetic Analysis Creates New Models and Strengthens the Old

Ist Teil von

• American journal of transplantation, 2012-04, Vol.12 (4), p.812-819

Ort / Verlag

Malden, USA: Blackwell Publishing Inc

Erscheinungsjahr

2012

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• Nonhuman primate (NHP) models play a critical role in the translation of novel therapies for transplantation to the clinic. However, although MHC disparity significantly affects the outcome of transplantation, until recently, experiments using NHP models were performed without the ability to rigorously control the degree of MHC disparity in transplant cohorts. In this review, we discuss several key technical breakthroughs in the field, which have finally enabled detailed immunogenetic data to be incorporated into NHP transplantation studies. These advances have created a new gold‐standard for NHP transplantation research, which incorporates detailed information regarding the degree of relatedness and the degree of MHC haplotype disparity between transplant pairs and the precise MHC alleles that both donors and recipients express. The adoption of this new standard promises to increase the rigor of NHP transplantation studies and to ensure that these experiments are optimally translatable to patient care. This review discusses recent technical breakthroughs in the field of immunogenetic analysis of nonhuman primate (NHP) transplant models, which have finally enabled key immunogenetic data to be incorporated into NHP transplantation studies and which are creating a new gold standard for NHP transplantation tolerance research.