Details

Autor(en) / Beteiligte

• Duell, E.J.
• Lucenteforte, E.
• Olson, S.H.
• Bracci, P.M.
• Li, D.
• Risch, H.A.
• Silverman, D.T.
• Ji, B.T.
• Gallinger, S.
• Holly, E.A.
• Fontham, E.H.
• Maisonneuve, P.
• Bueno-de-Mesquita, H.B.
• Ghadirian, P.
• Kurtz, R.C.
• Ludwig, E.
• Yu, H.
• Lowenfels, A.B.
• Seminara, D.
• Petersen, G.M.
• La Vecchia, C.
• Boffetta, P.

Titel

Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Ist Teil von

• Annals of oncology, 2012-11, Vol.23 (11), p.2964-2970

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case–control studies (5048 cases of ductal pancreatic adenocarcinoma and 10 947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96–3.74) and much stronger at intervals of ≤2 years (OR: 13.56, 95% CI: 8.72–21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (<65 years) pancreatic cancer cases showed stronger associations with previous (>2 years) pancreatitis (OR: 3.91, 95% CI: 2.53–6.04) than the older (≥65 years) cases (OR: 1.68, 95% CI: 1.02–2.76; P value for interaction: 0.006). Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612–2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented.