Details

Autor(en) / Beteiligte

• Kahn, Julia B
• Ward, Ryan D
• Kahn, Lora W
• Rudy, Nicole M
• Kandel, Eric R
• Balsam, Peter D
• Simpson, Eleanor H

Titel

Medial Prefrontal Lesions in Mice Impair Sustained Attention but Spare Maintenance of Information in Working Memory

Ist Teil von

• Learning & memory (Cold Spring Harbor, N.Y.), 2012-11, Vol.19 (11), p.513-517

Ort / Verlag

United States: Cold Spring Harbor Laboratory Press

Erscheinungsjahr

2012

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Working memory and attention are complex cognitive functions that are disrupted in several neuropsychiatric disorders. Mouse models of such human diseases are commonly subjected to maze-based tests that can neither distinguish between these cognitive functions nor isolate specific aspects of either function. Here, we have adapted a simple visual discrimination task, and by varying only the timing of events within the same task construct, we are able to measure independently the behavioral response to increasing attentional demand and increasing length of time that information must be maintained in working memory. We determined that mPFC lesions in mice impair attention but not working memory maintenance.