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Cell-free fetal DNA testing for fetal aneuploidy and beyond: clinical integration challenges in the US context
Ist Teil von
Human reproduction (Oxford), 2012-11, Vol.27 (11), p.3123-3131
Ort / Verlag
Oxford: Oxford University Press
Erscheinungsjahr
2012
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
The recent release of new, non-invasive prenatal tests for fetal aneuploidy using cell-free fetal DNA (cffDNA) has been hailed as a revolution in prenatal testing and has triggered significant commercial interest in the field. Ongoing research portends the arrival of a wide range of cffDNA tests. However, it is not yet clear how these tests will be integrated into well-established prenatal testing strategies in the USA, as the timing of such testing and the degree to which new non-invasive tests will supplement or replace existing screening and diagnostic tools remain uncertain. We argue that there is an urgent need for policy-makers, regulators and professional societies to provide guidance on the most efficient and ethical manner for such tests to be introduced into clinical practice in the USA.