Journal of molecular endocrinology, 2012-12, Vol.49 (3), p.R135-R148
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Multiple roles of COUP-TFII in cancer initiation and progression
- Ist Teil von
- Journal of molecular endocrinology, 2012-12, Vol.49 (3), p.R135-R148
- Ort / Verlag
- England: Society for Endocrinology
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is an orphan nuclear receptor that acts as a transcriptional activator or repressor in a cell type-dependent manner. Best characterized for its role in the regulation of angiogenesis during mouse development, COUP-TFII also plays important roles in glucose metabolism and cancer. Expression of COUP-TFII is altered in various endocrine conditions. Cell type-specific functions and the regulation of COUP-TFII expression result in its varying physiological and pathological actions in diverse systems. Evidence will be reviewed for oncogenic and tumor-suppressive functions of COUP-TFII, with roles in angiogenesis, metastasis, steroidogenesis, and endocrine sensitivity of breast cancer described. The applicability of current data to our understanding of the role of COUP-TFII in cancer will be discussed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0952-5041eISSN: 1479-6813DOI: 10.1530/JME-12-0144Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3469769
- Format
- –
- Schlagworte
- Animals, COUP Transcription Factor II - genetics, COUP Transcription Factor II - metabolism, Humans, Models, Biological, Neoplasms - genetics, Neoplasms - metabolism, Neoplasms - pathology, Neovascularization, Pathologic - genetics, Neovascularization, Pathologic - metabolism, Neovascularization, Pathologic - pathology, Review, Signal Transduction - genetics, Signal Transduction - physiology