The Journal of clinical investigation, 2012-10, Vol.122 (10), p.3791-3795
2012
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- Autor(en) / Beteiligte
- Titel
- Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
- Ist Teil von
- The Journal of clinical investigation, 2012-10, Vol.122 (10), p.3791-3795
- Ort / Verlag
- United States: American Society for Clinical Investigation
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25-34. Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release. Kisspeptin neurons, which express prolactin receptors, were recently identified as major regulators of GnRH neurons. To mimic the human pathology of anovulation, we continuously infused female mice with prolactin. Our studies demonstrated that hyperprolactinemia in mice induced anovulation, reduced GnRH and gonadotropin secretion, and diminished kisspeptin expression. Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. Our studies indicate that administration of kisspeptin may serve as an alternative therapeutic approach to restore the fertility of hyperprolactinemic women who are resistant or intolerant to dopamine agonists.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9738eISSN: 1558-8238DOI: 10.1172/jci63937Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3461919
- Format
- –
- Schlagworte
- Animals, Anovulation - drug therapy, Anovulation - etiology, Anovulation - physiopathology, Biomedical research, Brief Report, Disease Models, Animal, Dopamine, Drug Evaluation, Preclinical, Estrous Cycle - drug effects, Experiments, Female, Females, Gene expression, Gene Expression Regulation - drug effects, Genetic aspects, Gonadotropin releasing hormone, Gonadotropin-Releasing Hormone - secretion, Gonadotropins, Pituitary - biosynthesis, Gonadotropins, Pituitary - blood, Gonadotropins, Pituitary - secretion, Health aspects, Hyperprolactinemia, Hyperprolactinemia - chemically induced, Hyperprolactinemia - complications, Hyperprolactinemia - drug therapy, Hyperprolactinemia - physiopathology, Hypothalamo-Hypophyseal System - drug effects, Hypothalamo-Hypophyseal System - physiology, Hypothalamus - drug effects, Hypothalamus - metabolism, Hypothalamus - secretion, Infertility, Infusion Pumps, Implantable, Kisspeptins - biosynthesis, Kisspeptins - genetics, Kisspeptins - therapeutic use, Life Sciences, Male, Mice, Neurons, Other, Ovaries, Ovulation, Physiological aspects, Prolactin - administration & dosage, Prolactin - toxicity, Pulsatile Flow, RNA, Messenger - biosynthesis, RNA, Messenger - genetics