Details

Autor(en) / Beteiligte

• Rossi, Lara
• Lin, Kuanyin K.
• Boles, Nathan C.
• Yang, Liubin
• King, Katherine Y.
• Jeong, Mira
• Mayle, Allison
• Goodell, Margaret A.

Titel

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

Ist Teil von

• Cell stem cell, 2012-09, Vol.11 (3), p.302-317

Ort / Verlag

Cambridge, MA: Elsevier Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC function in knockout mice. In this review, we compile the majority of these reports to provide a broad overview of the functional modules revealed by these genetic analyses and highlight some key regulatory pathways involved, including cell cycle control, Tgf-β signaling, Pten/Akt signaling, Wnt signaling, and cytokine signaling. Finally, we propose recommendations for characterization of HSC function in knockout mice to facilitate cross-study comparisons that would generate a more cohesive picture of HSC biology.