Details

Autor(en) / Beteiligte

• Shankaran, Seetha
• Pappas, Athina
• McDonald, Scott A
• Vohr, Betty R
• Hintz, Susan R
• Yolton, Kimberly
• Gustafson, Kathryn E
• Leach, Theresa M
• Green, Charles
• Bara, Rebecca
• Huitema, Carolyn M. Petrie
• Ehrenkranz, Richard A
• Tyson, Jon E
• Das, Abhik
• Hammond, Jane
• Peralta-Carcelen, Myriam
• Evans, Patricia W
• Heyne, Roy J
• Wilson-Costello, Deanne E
• Vaucher, Yvonne E
• Bauer, Charles R
• Dusick, Anna M
• Adams-Chapman, Ira
• Goldstein, Ricki F
• Guillet, Ronnie
• Papile, Lu-Ann
• Higgins, Rosemary D

Titel

Childhood Outcomes after Hypothermia for Neonatal Encephalopathy

Ist Teil von

• The New England journal of medicine, 2012-05, Vol.366 (22), p.2085-2092

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• A prior report on hypothermia for neonatal hypoxic–ischemic encephalopathy showed a reduced rate of death or disability at 18 to 22 months of age. In this report of outcomes at 6 to 7 years, rates of death or an IQ below 70 were nonsignificantly lower with hypothermia than with usual care. Moderate or severe neonatal hypoxic–ischemic encephalopathy is associated with a high incidence of death or motor and sensory disability in children. 1 – 5 Children with encephalopathy are at risk for cognitive deficits even in the absence of functional deficits. Survivors without disability have delayed entry into primary school and fine-motor dysfunction and behavioral abnormalities. Hypothermia to 33 to 34°C for 72 hours, when initiated within 6 hours after birth among infants of more than 35 weeks' gestational age with hypoxic–ischemic encephalopathy, has been shown to reduce the risk of death or disability and increase the rate of survival free of disability . . .