Details

Autor(en) / Beteiligte

• Borini, A.
• Prato, L. Dal
• Bianchi, L.
• Violini, F.
• Cattoli, M.
• Flamigni, C.

Titel

CLINICAL ASSISTED REPRODUCTION: Effect of Duration of Estradiol Replacement on the Outcome of Oocyte Donation

Ist Teil von

• Journal of assisted reproduction and genetics, 2001-04, Vol.18 (4), p.187-192

Ort / Verlag

New York: Kluwer Academic Publishers-Plenum Publishers

Erscheinungsjahr

2001

Link zum Volltext

Quelle

SpringerLINK Contemporary (Konsortium Baden-Württemberg)

Beschreibungen/Notizen

• Purpose: To investigate if duration of estrogenic endometrial stimulation can affect recipient pregnancy rate in an ovum donation program. Methods: Each recipient received micronized 17 β-estradiol orally in a steadily increasing dosage from 2 to 6 mg daily over a period of time varying from 5 to 76 days until oocyte were available for donation. Recipients (520 patients for a total of 835 transfer cycles) were retrospectively divided into five groups depending on the duration of E 2 administration. Results: No significant difference was seen in pregnancy and implantation rates between groups. There was a higher number of miscarriages in Group A (41%), p < 0.05 vs. Group B (15%), and vs. Group E (1%). Age, number of pregnancies and miscarriages, or implantation rate in donors (327 women aged <35 years) were similar in all the five groups. Conclusions: Endometrial receptivity is tolerant to a wide duration of E 2 treatment (until 2 months), while waiting for oocytes available for donation, but best results are achieved with a treatment range of 11 to about 40 days.