Breast cancer research : BCR, 2012-03, Vol.14 (2), p.303-303, Article 303
2012
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- Autor(en) / Beteiligte
- Titel
- Are breast cancers driven by fusion genes?
- Ist Teil von
- Breast cancer research : BCR, 2012-03, Vol.14 (2), p.303-303, Article 303
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- For many years, it was assumed that gene fusions were a type of mutation confined largely to leukemias and sarcomas. However, fusion genes are now known to be important in several epithelial cancers and a number have been described in breast cancers. In the December 2011 issue of Nature Medicine, Robinson and colleagues reported many more gene fusions -including the first recurrent fusion, SEC16A-NOTCH1 - in breast cancers. Several genes, including members of the MAST (microtubule-associated serine threonine) kinase and Notch gene families, are fused more than once. This finding supports an emerging story that most breast cancers express a number of fusion genes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1465-542X, 1465-5411eISSN: 1465-542XDOI: 10.1186/bcr3122Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3446366
- Format
- –
- Schlagworte
- Breast cancer, Breast Neoplasms - genetics, Cancer genetics, Female, Fusion Proteins, bcr-abl - genetics, Gene Fusion, Genes, Genetic aspects, Humans, Leukemia, Male, Microtubule-Associated Proteins - genetics, Prostatic Neoplasms - genetics, Protein Serine-Threonine Kinases - genetics, Receptor, Notch1 - genetics, Sarcoma, Vesicular Transport Proteins - genetics, Viewpoint