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Molecular Identity and Functional Properties of the Mitochondrial Na+/Ca2+ Exchanger
Ist Teil von
The Journal of biological chemistry, 2012-09, Vol.287 (38), p.31650-31657
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2012
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The mitochondrial membrane potential that powers the generation of ATP also facilitates mitochondrial Ca2+ shuttling. This process is fundamental to a wide range of cellular activities, as it regulates ATP production, shapes cytosolic and endoplasmic recticulum Ca2+ signaling, and determines cell fate. Mitochondrial Ca2+ transport is mediated primarily by two major transporters: a Ca2+ uniporter that mediates Ca2+ uptake and a Na+/Ca2+ exchanger that subsequently extrudes mitochondrial Ca2+. In this minireview, we focus on the specific role of the mitochondrial Na+/Ca2+ exchanger and describe its ion exchange mechanism, regulation by ions, and putative partner proteins. We discuss the recent molecular identification of the mitochondrial exchanger and how its activity is linked to physiological and pathophysiological processes.