Annals of the New York Academy of Sciences, 2011-07, Vol.1229 (1), p.29-37
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism
- Ist Teil von
- Annals of the New York Academy of Sciences, 2011-07, Vol.1229 (1), p.29-37
- Ort / Verlag
- Malden, USA: Blackwell Publishing Inc
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH–STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH–STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH–STAT5 in sex‐specific gene expression and bile acid, steroid, and drug metabolism.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0077-8923eISSN: 1749-6632DOI: 10.1111/j.1749-6632.2011.06100.xTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3427656
- Format
- –
- Schlagworte
- Animals, Bile, Bile Acids and Salts - metabolism, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - metabolism, Cell Cycle, Control, Fibrosis, Gene expression, Gene Expression Regulation, growth hormone, Growth Hormone - genetics, Growth Hormone - metabolism, Growth hormones, Human Growth Hormone - genetics, Human Growth Hormone - metabolism, Humans, Lipid Metabolism, Liver, Liver - metabolism, Liver cancer, liver function, Liver Neoplasms - genetics, Liver Neoplasms - metabolism, Metabolism, Signal Transduction, STAT5, STAT5 Transcription Factor - metabolism, Steroids, Transducers