Details

Autor(en) / Beteiligte

• Pui, Ching-Hon
• Mullighan, Charles G.
• Evans, William E.
• Relling, Mary V.

Titel

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

Ist Teil von

• Blood, 2012-08, Vol.120 (6), p.1165-1174

Ort / Verlag

Washington, DC: Elsevier Inc

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Improved supportive care, more precise risk stratification, and personalized chemotherapy based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and pharmacogenetics) have pushed the cure rate of childhood acute lymphoblastic leukemia to near 90%. Further increase in cure rate can be expected from the discovery of additional recurrent molecular lesions, coupled with the development of novel targeted treatment through high-throughput genomics and innovative drug-screening systems. We discuss specific areas of research that promise to further refine current treatment and to improve the cure rate and quality of life of the patients.