Trends in microbiology (Regular ed.), 2012-08, Vol.20 (8), p.392-401
2012
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- Autor(en) / Beteiligte
- Titel
- Viral and host control of cytomegalovirus maturation
- Ist Teil von
- Trends in microbiology (Regular ed.), 2012-08, Vol.20 (8), p.392-401
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Maturation in herpesviruses initiates in the nucleus of the infected cell, with encapsidation of viral DNA to form nucleocapsids, and concludes with envelopment in the cytoplasm to form infectious virions that egress the cell. The entire process of virus maturation is orchestrated by protein–protein interactions and enzymatic activities of viral and host origin. Viral tegument proteins play important roles in maintaining the structural stability of capsids and directing the acquisition of virus envelope. Envelopment occurs at modified host membranes and exploits host vesicular trafficking. In this review, we summarize current knowledge of and concepts in human cytomegalovirus (HCMV) maturation and their parallels in other herpesviruses, with an emphasis on viral and host factors that regulate this process.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0966-842XeISSN: 1878-4380DOI: 10.1016/j.tim.2012.04.008Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3408842
- Format
- –
- Schlagworte
- betaherpesviruses, capsid, Cell Nucleus - virology, Cytomegalovirus - genetics, Cytomegalovirus - metabolism, Cytomegalovirus - physiology, cytoplasm, DNA, DNA, Viral - genetics, envelope, enzyme activity, Herpesviridae - physiology, Host-Derived Cellular Factors - physiology, Host-Pathogen Interactions, Human herpesvirus 5, Humans, Internal Medicine, nuclear egress, nucleocapsid, Nucleocapsid - physiology, nucleocapsids, protein-protein interactions, proteins, replication, virion, Virus Replication - physiology, viruses