Details

Autor(en) / Beteiligte

• Mourot, Alexandre
• Kienzler, Michael A
• Banghart, Matthew R
• Fehrentz, Timm
• Huber, Florian M. E
• Stein, Marco
• Kramer, Richard H
• Trauner, Dirk

Titel

Tuning Photochromic Ion Channel Blockers

Ist Teil von

• ACS chemical neuroscience, 2011-09, Vol.2 (9), p.536-543

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Photochromic channel blockers provide a conceptually simple and convenient way to modulate neuronal activity with light. We have recently described a family of azobenzenes that function as tonic blockers of Kv channels but require UV-A light to unblock and need to be actively switched by toggling between two different wavelengths. We now introduce red-shifted compounds that fully operate in the visible region of the spectrum and quickly turn themselves off in the dark. Furthermore, we have developed a version that does not block effectively in the dark-adapted state, can be switched to a blocking state with blue light, and reverts to the inactive state automatically. Photochromic blockers of this type could be useful for the photopharmacological control of neuronal activity under mild conditions.