European journal of clinical nutrition, 2012-09, Vol.66 (9), p.983-988
2012
Details
- Autor(en) / Beteiligte
- Titel
- MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults
- Ist Teil von
- European journal of clinical nutrition, 2012-09, Vol.66 (9), p.983-988
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Recent research has shown an inverse relationship between bone marrow adipose tissue (BMAT) and bone mineral density (BMD). There is a lack of evidence at the macro-imaging level to establish whether increased BMAT is a cause or effect of bone loss. This cross-sectional study compared the BMAT and BMD relationship between a younger adult group at or approaching peak bone mass (PBM; age 18.0-39.9 years) and an older group with potential bone loss (PoBL; age 40.0-88.0 years). Pelvic BMAT was evaluated in 560 healthy men and women with T1-weighted whole-body magnetic resonance imaging. BMD was measured using whole-body dual-energy X-ray absorptiometry. An inverse correlation was observed between pelvic BMAT and pelvic, total and spine BMD in the younger PBM group (r=-0.419 to -0.461, P<0.001) and in the older PoBL group (r=-0.405 to -0.500, P<0.001). After adjusting for age, sex, ethnicity, menopausal status, total body fat, skeletal muscle, subcutaneous and visceral adipose tissue, neither subject group (younger PBM vs older PoBL) nor its interaction with pelvic BMAT significantly contributed to the regression models with BMD as dependent variable and pelvic BMAT as independent variable (P=0.434-0.928). Our findings indicate that an inverse relationship between pelvic BMAT and BMD is present both in younger subjects who have not yet experienced bone loss and also in older subjects. These results provide support at the macro-imaging level for the hypothesis that low BMD may be a result of preferential differentiation of mesenchymal stem cells from osteoblasts to adipocytes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0954-3007eISSN: 1476-5640DOI: 10.1038/ejcn.2012.35Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3396793
- Format
- –
- Schlagworte
- Absorptiometry, Photon, Adipocytes, Adipose tissue, Adipose tissues, Adolescent, Adult, Age, Age Factors, Aged, Aged, 80 and over, Aging, Biological and medical sciences, Biomedical materials, Body fat, Bone density, Bone Density - physiology, Bone loss, Bone marrow, Bone Marrow - metabolism, Bone mass, Bone mineral density, Bones, Cell differentiation, Cross-Sectional Studies, Density, Dependent variables, Dual energy X-ray absorptiometry, Feeding. Feeding behavior, Female, Fundamental and applied biological sciences. Psychology, Health aspects, Humans, Independent variables, Intra-Abdominal Fat - metabolism, Investigative techniques, diagnostic techniques (general aspects), Lumbar Vertebrae - metabolism, Magnetic Resonance Imaging, Male, Medical imaging, Medical sciences, Men, Menopause, Mesenchyme, Metabolic diseases, Middle Aged, Minerals - metabolism, Minority & ethnic groups, Muscles, Older people, Osteoarticular system. Muscles, Osteoblastogenesis, Pelvic Bones - metabolism, Pelvis, Physiological aspects, Radiodiagnosis. Nmr imagery. Nmr spectrometry, Regression Analysis, Regression models, Skeletal muscle, Spine, Stem cells, Subcutaneous Fat - metabolism, Vertebrates: anatomy and physiology, studies on body, several organs or systems, Young Adult