Details

Autor(en) / Beteiligte

• John-Stewart, Grace C.
• Nduati, Ruth W.
• Rousseau, Christine M.
• Mbori-Ngacha, Dorothy A.
• Richardson, Barbra A.
• Rainwater, Stephanie
• Panteleeff, Dana D.
• Overbaugh, Julie

Titel

Subtype C Is Associated with Increased Vaginal Shedding of HIV-1

Ist Teil von

• The Journal of infectious diseases, 2005-08, Vol.192 (3), p.492-496

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2005

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The prevalence of human immunodeficiency virus (HIV)–1–infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1–infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4–8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1–8.6]; P=.03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1