UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 6 von 87
Datensatz exportieren als...
BibTeX
FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: A report from the Children's Oncology Group
Pediatric blood & cancer, 2012-10, Vol.59 (4), p.662-667
Kutny, Matthew A.
Moser, Barry K.
Laumann, Kristina
Feusner, James H.
Gamis, Alan
Gregory, John
Larson, Richard A.
Powell, Bayard L.
Stock, Wendy
Willman, Cheryl L.
Woods, William G.
Meshinchi, Soheil
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Kutny, Matthew A.
Moser, Barry K.
Laumann, Kristina
Feusner, James H.
Gamis, Alan
Gregory, John
Larson, Richard A.
Powell, Bayard L.
Stock, Wendy
Willman, Cheryl L.
Woods, William G.
Meshinchi, Soheil
Titel
FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: A report from the Children's Oncology Group
Ist Teil von
Pediatric blood & cancer, 2012-10, Vol.59 (4), p.662-667
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
Background FLT3 mutations (FLT3/Mut) are prevalent in de novo AML and are associated with early relapse. The prevalence and prognostic significance of FLT3/Mut have not been well defined in childhood acute promyelocytic leukemia (APL). Procedure Diagnostic specimens from 104 pediatric APL patients were screened for FLT3/Mut (FLT3/ITD or FLT3/ALM). FLT3/Mut status was correlated with disease characteristics and clinical outcome for patients treated on CALGB C9710 (n = 50). Results Forty‐two of the 104 patients (40%) had either FLT3/ITD (n = 28, 27%) or FLT3/ALM (n = 15, 14%). Median diagnostic WBC count was 23,400 cells/µl vs. 3,600 cells/µl for those with and without FLT3/Mut (P < 0.001), and similar results for the cohort of 50 patients treated on C9710 (P < 0.001). In patients treated on C9710, presence of a FLT3 mutation was highly correlated with diagnostic WBC count >10,000 (P = 0.004), microgranular variant histology (P = 0.035), and a lower remission rate (P = 0.009). In patients who received ATRA (C9710 or CCG‐2911, n = 58), those with FLT3/Mut had an induction death rate of 30% (7/23) compared to 3% (1/35) in FLT3/WT patients (P = 0.005). In patients with high WBC counts (>10,000), those with FLT3/Mut had a significantly higher risk of induction death versus FLT3/WT patients (47% vs. 0%, P = 0.05). FLT3/Mut was not associated with adverse outcome in those who survived induction therapy. Conclusions FLT3/Mut are prevalent in pediatric APL and are associated with high WBC count and increased induction death. This study provides further evidence for testing APL patients for FLT3/Mut and the potential role for FLT3 inhibitors in this disease. Pediatr Blood Cancer 2012;59:662–667. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1545-5009
eISSN: 1545-5017
DOI: 10.1002/pbc.24122
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3368997
Format
–
Schlagworte
acute promyelocytic leukemia
,
Adolescent
,
APL
,
Child
,
Child, Preschool
,
Disease-Free Survival
,
Female
,
FLT3 mutation
,
fms-Like Tyrosine Kinase 3 - genetics
,
Humans
,
Infant
,
Leukemia, Promyelocytic, Acute - blood
,
Leukemia, Promyelocytic, Acute - genetics
,
Leukemia, Promyelocytic, Acute - mortality
,
Leukemia, Promyelocytic, Acute - therapy
,
Leukocyte Count
,
Male
,
Mutation
,
pediatric
,
Prognosis
,
Survival Rate
,
Young Adult
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX