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Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging
Magnetic resonance in medicine, 2012-05, Vol.67 (5), p.1252-1265
Dai, Weiying
Robson, Philip M
Shankaranarayanan, Ajit
Alsop, David C.
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Dai, Weiying
Robson, Philip M
Shankaranarayanan, Ajit
Alsop, David C.
Titel
Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging
Ist Teil von
Magnetic resonance in medicine, 2012-05, Vol.67 (5), p.1252-1265
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Arterial spin labeling perfusion MRI can suffer from artifacts and quantification errors when the time delay between labeling and arrival of labeled blood in the tissue is uncertain. This transit delay is particularly uncertain in broad clinical populations, where reduced or collateral flow may occur. Measurement of transit delay by acquisition of the arterial spin labeling signal at many different time delays typically extends the imaging time and degrades the sensitivity of the resulting perfusion images. Acquisition of transit delay maps at the same spatial resolution as perfusion images may not be necessary, however, because transit delay maps tend to contain little high spatial resolution information. Here, we propose the use of a reduced spatial resolution arterial spin labeling prescan for the rapid measurement of transit delay. Approaches to using the derived transit delay information to optimize and quantify higher resolution continuous arterial spin labeling perfusion images are described. Results in normal volunteers demonstrate heterogeneity of transit delay across different brain regions that lead to quantification errors without the transit maps and demonstrate the feasibility of this approach to perfusion and transit delay quantification. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194
eISSN: 1522-2594
DOI: 10.1002/mrm.23103
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3367437
Format
–
Schlagworte
Algorithms
,
arterial spin labeling
,
Blood Flow Velocity - physiology
,
Brain - anatomy & histology
,
Brain - physiology
,
cerebral blood flow
,
Cerebrovascular Circulation - physiology
,
Female
,
Humans
,
Image Enhancement - methods
,
Image Interpretation, Computer-Assisted - methods
,
Magnetic Resonance Angiography - methods
,
Male
,
perfusion imaging
,
Reproducibility of Results
,
Sensitivity and Specificity
,
transit delay
,
vessel suppression
,
Young Adult
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