Neuroscience, 2012-06, Vol.212, p.180-189
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion
- Ist Teil von
- Neuroscience, 2012-06, Vol.212, p.180-189
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► Both MMP-2 and MMP-9 were upregulated and activated in the early ischemic brain. ► MMP-9 KO decreased hemorrhagic volume in the cortex, but not in the striatum. ► MMP-2 KO and MMP-2/9 dKO reduced hemorrhagic volume in both cortex and striatum. ► MMP-2 KO and MMP-2/9 dKO was more protective than MMP-9 KO against brain HT. ► MMP-2 and/or -9 KO protected against brain infarct and neurological deficits.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2012.03.036Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3367043
- Format
- –
- Schlagworte
- Animals, Basal ganglia, Biological and medical sciences, Brain injury, Brain Ischemia - enzymology, Brain Ischemia - genetics, Brain Ischemia - physiopathology, Cerebral blood flow, Cerebral Hemorrhage - enzymology, Cerebral Hemorrhage - genetics, Cerebral Hemorrhage - physiopathology, cerebral ischemia, Chromium, Cortex, Disease Models, Animal, Female, Fundamental and applied biological sciences. Psychology, Gelatinase A, Gelatinase B, Hemorrhage, hemorrhagic transformation, Ischemia, Male, Matrix Metalloproteinase 2 - deficiency, Matrix Metalloproteinase 2 - genetics, Matrix Metalloproteinase 9 - deficiency, Matrix Metalloproteinase 9 - genetics, Medical sciences, Mice, Mice, Inbred C57BL, Mice, Knockout, MMP-2 knockout, MMP-2/9 double knockout, MMP-9 knockout, Neostriatum, Nervous system, Neurology, plasminogen, Reperfusion, Reperfusion Injury - enzymology, Reperfusion Injury - genetics, Reperfusion Injury - physiopathology, Transformation, Vascular diseases and vascular malformations of the nervous system, Vertebrates: nervous system and sense organs