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Vitamin D–binding protein modifies the vitamin D–bone mineral density relationship
Journal of bone and mineral research, 2011-07, Vol.26 (7), p.1609-1616
Powe, Camille E
Ricciardi, Catherine
Berg, Anders H
Erdenesanaa, Delger
Collerone, Gina
Ankers, Elizabeth
Wenger, Julia
Karumanchi, S Ananth
Thadhani, Ravi
Bhan, Ishir
2011
Details
Autor(en) / Beteiligte
Powe, Camille E
Ricciardi, Catherine
Berg, Anders H
Erdenesanaa, Delger
Collerone, Gina
Ankers, Elizabeth
Wenger, Julia
Karumanchi, S Ananth
Thadhani, Ravi
Bhan, Ishir
Titel
Vitamin D–binding protein modifies the vitamin D–bone mineral density relationship
Ist Teil von
Journal of bone and mineral research, 2011-07, Vol.26 (7), p.1609-1616
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Studies examining the relationship between total circulating 25‐hydroxyvitamin D [25(OH)D] levels and bone mineral density (BMD) have yielded mixed results. Vitamin D–binding protein (DBP), the major carrier protein for 25(OH)D, may alter the biologic activity of circulating vitamin D. We hypothesized that free and bioavailable 25(OH)D, calculated from total 25(OH)D, DBP, and serum albumin levels, would be more strongly associated with BMD than levels of total 25(OH)D. We measured total 25(OH)D, DBP, and serum albumin levels in 49 healthy young adults enrolled in the Metabolic Abnormalities in College‐Aged Students (MACS) study. Lumbar spine BMD was measured in all subjects using dual‐energy X‐ray absorptiometry. Clinical, diet, and laboratory information also was gathered at this time. We determined free and bioavailable (free + albumin‐bound) 25(OH)D using previously validated formulas and examined their associations with BMD. BMD was not associated with total 25(OH)D levels (r = 0.172, p = .236). In contrast, free and bioavailable 25(OH)D levels were positively correlated with BMD (r = 0.413, p = .003 for free, r = 0.441, p = .002 for bioavailable). Bioavailable 25(OH)D levels remained independently associated with BMD in multivariate regression models adjusting for age, sex, body mass index, and race (p = .03). It is concluded that free and bioavailable 25(OH)D are more strongly correlated with BMD than total 25(OH)D. These findings have important implications for vitamin D supplementation in vitamin D–deficient states. Future studies should continue to explore the relationship between free and bioavailable 25(OH)D and health outcomes. © 2011 American Society for Bone and Mineral Research.
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.387
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3351032
Format
–
Schlagworte
Adult
,
Biological and medical sciences
,
Biological Availability
,
Bone Density - physiology
,
Bone mineral density
,
Female
,
Free hormone hypothesis
,
Fundamental and applied biological sciences. Psychology
,
Humans
,
Lumbar Vertebrae - physiology
,
Male
,
Original
,
Skeleton and joints
,
Vertebrates: osteoarticular system, musculoskeletal system
,
Vitamin D
,
Vitamin D - analogs & derivatives
,
Vitamin D - blood
,
Vitamin D deficiency
,
Vitamin D-Binding Protein - blood
,
Vitamin D–binding protein
,
Young Adult
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