Details

Autor(en) / Beteiligte

• Klinge, Carolyn M

Titel

miRNAs and estrogen action

Ist Teil von

• Trends in endocrinology and metabolism, 2012-05, Vol.23 (5), p.223-233

Ort / Verlag

Cambridge, MA: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• MicroRNAs (miRNAs) are short, noncoding RNAs that generally base-pair within the 3′ untranslated region of target mRNAs causing translational inhibition and/or mRNA degradation. Estradiol (E2 ) and other estrogen receptor (ER) ligands suppress or stimulate miRNA expression in human breast cancer cells, endometrial cells, rat mammary gland, and mouse uterus, and post-translationally regulate protein expression. Aberrant miRNA expression is implicated in estrogen-related breast and endometrial cancers, and several miRNAs downregulate ERα. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in health and disease is a ‘hot’ area of research that will yield new insight into molecular mechanisms of estrogen action.