Details

Autor(en) / Beteiligte

• Wagner, Daniel E.
• Wang, Irving E.
• Reddien, Peter W.

Titel

Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration

Ist Teil von

• Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6031), p.811-816

Ort / Verlag

Washington, DC: American Association for the Advancement of Science

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• Pluripotent cells in the embryo can generate all cell types, but lineage-restricted cells are generally thought to replenish adult tissues. Planarians are flatworms and regenerate from tiny body fragments, a process requiring a population of proliferating cells (neoblasts). Whether regeneration is accomplished by pluripotent cells or by the collective activity of multiple lineage-restricted cell types is unknown. We used ionizing radiation and single-cell transplantation to identify neoblasts that can form large descendant-cell colonies in vivo. These clonogenic neoblasts (cNeoblasts) produce cells that differentiate into neuronal, intestinal, and other known postmitotic cell types and are distributed throughout the body. Single transplanted cNeoblasts restored regeneration in lethally irradiated hosts. We conclude that broadly distributed, adult pluripotent stem cells underlie the remarkable regenerative abilities of planarians.