Details

Autor(en) / Beteiligte

• Kelsey, Ellen Miriam
• Luo, Xi
• Brückner, Katja
• Jasper, Heinrich

Titel

Schnurri regulates hemocyte function to promote tissue recovery after DNA damage

Ist Teil von

• Journal of cell science, 2012-03, Vol.125 (Pt 6), p.1393-1400

Ort / Verlag

England: Company of Biologists

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Tissue recovery after injury requires coordinated regulation of cell repair and apoptosis, removal of dead cells and regeneration. A critical step in this process is the recruitment of blood cells that mediate local inflammatory and immune responses, promoting tissue recovery. Here we identify a new role for the transcriptional regulator Schnurri (Shn) in the recovery of UV-damaged Drosophila retina. Using an experimental paradigm that allows precise quantification of tissue recovery after a defined dose of UV, we find that Shn activity in the retina is required to limit tissue damage. This function of Shn relies on its transcriptional induction of the PDGF-related growth factor Pvf1, which signals to tissue-associated hemocytes. We show that the Pvf1 receptor PVR acts in hemocytes to induce a macrophage-like morphology and that this is required to limit tissue loss after irradiation. Our results identify a new Shn-regulated paracrine signaling interaction between damaged retinal cells and hemocytes that ensures recovery and homeostasis of the challenged tissue.