Details

Autor(en) / Beteiligte

• Lin, Zhicheng
• Canales, Juan J
• Björgvinsson, Thröstur
• Thomsen, Morgane
• Qu, Hong
• Liu, Qing-Rong
• Torres, Gonzalo E
• Caine, S Barak

Titel

Monoamine Transporters: Vulnerable and Vital Doorkeepers

Ist Teil von

• Progress in molecular biology and translational science, 2011, Vol.98, p.1-46

Ort / Verlag

United States: Elsevier Science & Technology

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Transporters of dopamine, serotonin, and norepinephrine have been empirically used as medication targets for several mental illnesses in the last decades. These protein-targeted medications are effective only for subpopulations of patients with transporter-related brain disorders. Since the cDNA clonings in early 1990s, molecular studies of these transporters have revealed a wealth of information about the transporters' structure-activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics, and the diseases related to the human genes encoding these transporters among related regulators. Such new information creates a unique opportunity to develop transporter-specific medications based on SAR, mRNA, DNA, and perhaps transporter trafficking regulation for a number of highly relevant diseases including substance abuse, depression, schizophrenia, and Parkinson's disease.