Details

Autor(en) / Beteiligte

• Bowen, Raffick A.R.
• Dowdell, Kennichi C.
• Dale, Janet K.
• Drake, Steven K.
• Fleisher, Thomas A.
• Hortin, Glen L.
• Remaley, Alan T.
• Nexo, Ebba
• Rao, V. Koneti

Titel

Elevated vitamin B12 levels in autoimmune lymphoproliferative syndrome attributable to elevated haptocorrin in lymphocytes

Ist Teil von

• Clinical biochemistry, 2012-04, Vol.45 (6), p.490-492

Ort / Verlag

Amsterdam: Elsevier Inc

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Identify the etiology of elevated B12 in autoimmune lymphoproliferative syndrome (ALPS). Peripheral blood of ALPS patients with elevated B12 and controls were evaluated. Total and holo-haptocorrin (HC) levels were 26- and 23-fold higher in ALPS patients, respectively. No abnormal B12-binding proteins were found. Western blot revealed HC in lymphocyte lysates only from ALPS patients. Elevated concentrations of B12 found in ALPS patients were due to increased lymphocyte expression of HC. [Display omitted] ► Vitamin B12 levels were significantly increased in ALPS-FAS patients. ► Serum total and holo-haptocorrin levels were elevated in ALPS-FAS patients. ► No abnormal serum vitamin B12-binding proteins were present in ALPS-FAS patients. ► Serum transcobalamin levels were not elevated in ALPS-FAS and control subjects. ► Haptocorrin were found in lymphocyte lysates of ALPS but not control subjects.