Science (American Association for the Advancement of Science), 2011-11, Vol.334 (6056), p.623-628
2011
Details
- Autor(en) / Beteiligte
- Titel
- The Cell Biology of Synaptic Plasticity
- Ist Teil von
- Science (American Association for the Advancement of Science), 2011-11, Vol.334 (6056), p.623-628
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Synaptic plasticity is the experience-dependent change in connectivity between neurons that is believed to underlie learning and memory. Here, we discuss the cellular and molecular processes that are altered when a neuron responds to external stimuli, and how these alterations lead to an increase or decrease in synaptic connectivity. Modification of synaptic components and changes in gene expression are necessary for many forms of plasticity. We focus on excitatory neurons in the mammalian hippocampus, one of the best-studied model systems of learning-related plasticity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1209236Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3286636
- Format
- –
- Schlagworte
- Anatomy, Animals, Behavioral neuroscience, Biological and medical sciences, Brain research, Cellular biology, Cytology, Dendrites, External stimuli, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Hippocampus - cytology, Hippocampus - physiology, Humans, Learning - physiology, Long term depression, Long term potentiation, Memory - physiology, Molecular biology, Neuroglia - physiology, Neurology, Neuronal Plasticity - genetics, Neuronal Plasticity - physiology, Neurons, Neurons - cytology, Neurons - physiology, Phosphorylation, Plasticity, Receptors, REVIEWS, Stimuli, Synapses, Synapses - physiology, Synaptic Transmission, Vertebrates: nervous system and sense organs