Details

Autor(en) / Beteiligte

• Liu, Fei
• Li, Bo
• Wang, Wen-Tao
• Wei, Yong-Gang
• Yan, Lv-Nan
• Wen, Tian-Fu
• Xu, Ming-Qing
• Yang, Jia-Yin

Titel

Interleukin-10-1082G/A polymorphism and acute liver graft rejection：A meta-analysis

Ist Teil von

• World journal of gastroenterology : WJG, 2012-02, Vol.18 (8), p.847-854

Ort / Verlag

United States: Baishideng Publishing Group Co., Limited

Erscheinungsjahr

2012

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• AIM： To investigate the association between interleukin （IL）-10-1082 （G/A） promoter polymorphism and acute rejection （AR） in liver transplant （LT） recipients. METHODS： Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios （ORs） and 95% CIs for IL-10-1082 G/A polymorphism and AR were calculated in a fixed and a random-effects model as appropriate. RESULTS： This meta-analysis included seven casecontrol studies, which comprised 652 cases of LT recipients in which 241 cases developed AR and 411 cases did not develop AR. Overall, the variant A allele was not associated with AR risk when compared with the wild-type G allele （OR = 0.94, 95% CI： 0.64-1.39）. Moreover, similar results were observed when the AA genotype was compared with the AG/GG genotype （OR = 1.05, 95% CI： 0.55-2.02）. When stratifying for eth-nicity, no significant association was observed among either Caucasians or Asians. Because only one study was performed in Asian patients, the result of subgroup analysis by ethnicity would not be reliable for Asians. Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study. CONCLUSION： This meta-analysis suggests that IL-10-1082 G/A polymorphism may be not associated with AR risk in LT recipients among Caucasians.