Details
- Autor(en) / Beteiligte
- Titel
- A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer
- Ist Teil von
- Cell stem cell, 2012-02, Vol.10 (2), p.183-197
- Ort / Verlag
- Cambridge, MA: Elsevier Inc
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Gene expression signatures relating mammary stem cell populations to breast cancers have focused on adult tissue. Here, we identify, isolate, and characterize the fetal mammary stem cell (fMaSC) state since the invasive and proliferative processes of mammogenesis resemble phases of cancer progression. fMaSC frequency peaks late in embryogenesis, enabling more extensive stem cell purification than achieved with adult tissue. fMaSCs are self-renewing, multipotent, and coexpress multiple mammary lineage markers. Gene expression, transplantation, and in vitro analyses reveal putative autocrine and paracrine regulatory mechanisms, including ErbB and FGF signaling pathways impinging on fMaSC growth. Expression profiles from fMaSCs and associated stroma exhibit significant similarities to basal-like and Her2+ intrinsic breast cancer subtypes. Our results reveal links between development and cancer and provide resources to identify new candidates for diagnosis, prognosis, and therapy. [Display omitted] ► Fetal mammary stem cells (fMaSC) increase sharply late in embryogenesis ► fMaSCs coexpress markers of multiple mammary lineages and are multipotent ► We elucidate growth factors and stromal interactions governing fMaSC function ► Expression profiles link fMaSCs and fetal stroma to human breast cancers
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1934-5909eISSN: 1875-9777DOI: 10.1016/j.stem.2011.12.018Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3277444
- Format
- –
- Schlagworte
- Animals, Biological and medical sciences, Breast Neoplasms - genetics, Breast Neoplasms - metabolism, Breast Neoplasms - pathology, Carcinoma, Basal Cell - genetics, Carcinoma, Basal Cell - metabolism, Carcinoma, Basal Cell - pathology, Cell differentiation, maturation, development, hematopoiesis, Cell physiology, Cell Survival, Cell Transformation, Neoplastic, Embryonic Stem Cells - metabolism, Embryonic Stem Cells - pathology, Female, Fibroblast Growth Factors - genetics, Fibroblast Growth Factors - metabolism, Fundamental and applied biological sciences. Psychology, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Gynecology. Andrology. Obstetrics, Humans, Mammary gland diseases, Mammary Glands, Human - embryology, Mammary Glands, Human - metabolism, Mammary Glands, Human - pathology, Medical sciences, Mice, Mice, SCID, Molecular and cellular biology, Neoplastic Stem Cells - metabolism, Neoplastic Stem Cells - pathology, Oncogene Proteins v-erbB - genetics, Oncogene Proteins v-erbB - metabolism, Pluripotent Stem Cells - metabolism, Pluripotent Stem Cells - pathology, Stem Cell Transplantation, Tumors