Details

Autor(en) / Beteiligte

• Erkan, Mert
• Adler, Guido
• Apte, Minoti V
• Bachem, Max G
• Buchholz, Malte
• Detlefsen, Sönke
• Esposito, Irene
• Friess, Helmut
• Gress, Thomas M
• Habisch, Hans-Joerg
• Hwang, Rosa F
• Jaster, Robert
• Kleeff, Jörg
• Klöppel, Günter
• Kordes, Claus
• Logsdon, Craig D
• Masamune, Atsushi
• Michalski, Christoph W
• Oh, Junseo
• Phillips, Phoebe A
• Pinzani, Massimo
• Reiser-Erkan, Carolin
• Tsukamoto, Hidekazu
• Wilson, Jeremy

Titel

StellaTUM: current consensus and discussion on pancreatic stellate cell research

Ist Teil von

• Gut, 2012-02, Vol.61 (2), p.172-178

Ort / Verlag

London: BMJ Publishing Group Ltd and British Society of Gastroenterology

Erscheinungsjahr

2012

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• In 2006, it was reported that BM is a source of myofibroblast-like cells in fibrotic liver tissue, but the involvement of these cells in the progression of liver fibrosis remains questionable as their contribution to collagen synthesis appears to be limited. 19 20 Recent studies have now also addressed the role of BM-derived cells in pancreatic regeneration and fibrosis. 21 22 Using a similar experimental approach, namely the transfer of green fluorescent protein (GFP)-expressing BM cells to lethally irradiated small rodents followed by the induction of chronic pancreatitis with cerulein or dibutyltin dichloride, it was consistently shown that BM-derived cells did home to the pancreas. 21 22 In both studies, the induction of chronic pancreatitis was found to be associated with an increase in the number of GFP-expressing PSC. [...]therapeutic strategies would be expected to reduce the fibrosis of chronic pancreatitis, thereby retarding the development of exocrine and endocrine insufficiency, and interrupt the interaction of PSC in the stromal reaction with pancreatic cancer cells, thereby inhibiting tumour progression and improving the otherwise dismal prognosis of this disease. [...]at present, the field of PSC research is dynamic and wide open, with significant potential for novel discoveries and major breakthroughs that could have a lasting impact on the treatment of patients with pancreatic diseases.