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Calcium intake and prostate cancer among African Americans: Effect modification by vitamin D receptor calcium absorption genotype
Journal of bone and mineral research, 2012-01, Vol.27 (1), p.187-194
Rowland, Glovioell W
Schwartz, Gary G
John, Esther M
Ingles, Sue Ann
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Rowland, Glovioell W
Schwartz, Gary G
John, Esther M
Ingles, Sue Ann
Titel
Calcium intake and prostate cancer among African Americans: Effect modification by vitamin D receptor calcium absorption genotype
Ist Teil von
Journal of bone and mineral research, 2012-01, Vol.27 (1), p.187-194
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
MEDLINE
Beschreibungen/Notizen
High dietary intake of calcium has been classified as a probable cause of prostate cancer, although the mechanism underlying the association between dietary calcium and prostate cancer risk is unclear. The vitamin D receptor (VDR) is a key regulator of calcium absorption. In the small intestine, VDR expression is regulated by the CDX‐2 transcription factor, which binds a polymorphic site in the VDR gene promoter. We examined VDR Cdx2 genotype and calcium intake, assessed by a food frequency questionnaire, in 533 African–American prostate cancer cases (256 with advanced stage at diagnosis, 277 with localized stage) and 250 African–American controls who participated in the California Collaborative Prostate Cancer Study. We examined the effects of genotype, calcium intake, and diet–gene interactions by conditional logistic regression. Compared with men in the lowest quartile of calcium intake, men in the highest quartile had an approximately twofold increased risk of localized and advanced prostate cancer (odds ratio [OR] = 2.20, 95% confidence interval [CI] = 1.40, 3.46), with a significant dose–response. Poor absorbers of calcium (VDR Cdx2 GG genotype) had a significantly lower risk of advanced prostate cancer (OR = 0.41, 95% CI = 0.19, 0.90). The gene–calcium interaction was statistically significant (p = 0.03). Among men with calcium intake below the median (680 mg/day), carriers of the G allele had an approximately 50% decreased risk compared with men with the AA genotype. These findings suggest a link between prostate cancer risk and high intestinal absorption of calcium. © 2012 American Society for Bone and Mineral Research
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.505
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3234334
Format
–
Schlagworte
AFRICAN-AMERICAN
,
Aged
,
Aged, 80 and over
,
Biological and medical sciences
,
Black or African American - genetics
,
Calcium - metabolism
,
CALCIUM ABSORPTION
,
Calcium, Dietary - pharmacology
,
Case-Control Studies
,
CDX2 Transcription Factor
,
Dietary Supplements
,
Fundamental and applied biological sciences. Psychology
,
GENETIC POLYMORPHISM
,
GENETIC POLYMORPHISM, PROSTATE CANCER
,
Homeodomain Proteins - metabolism
,
Humans
,
Intestinal Absorption - drug effects
,
Intestinal Absorption - genetics
,
Male
,
Middle Aged
,
Obesity - complications
,
Polymorphism, Genetic
,
PROSTATE CANCER
,
Prostatic Neoplasms - complications
,
Prostatic Neoplasms - genetics
,
Receptors, Calcitriol - genetics
,
Risk Factors
,
Skeleton and joints
,
Vertebrates: osteoarticular system, musculoskeletal system
,
VITAMIN D RECEPTOR
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