Details

Autor(en) / Beteiligte

• Mostoufi-Moab, Sogol, MD, MSCE
• Ginsberg, Jill P., MD
• Bunin, Nancy, MD
• Zemel, Babette S., PhD
• Shults, Justine, PhD
• Thayu, Meena, MD, MSCE
• Leonard, Mary B., MD, MSCE

Titel

Body Composition Abnormalities in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation

Ist Teil von

• The Journal of pediatrics, 2012-01, Vol.160 (1), p.122-128

Ort / Verlag

Maryland Heights, MO: Elsevier Inc

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To quantify lean mass (LM) and fat mass (FM) in survivors of childhood allogeneic hematopoietic stem-cell transplantation (alloHSCT) compared with healthy reference participants and identify risk factors for body composition abnormalities. Study design Whole body LM and FM were measured with dual energy x-ray absorptiometry in 54 survivors (ages 5-25 years) and 894 healthy reference participants in a cross-sectional study. Multivariate regression models were used to compare sex- and race-specific Z-scores for LM for height (LM-Ht) and FM for height (FM-Ht) in survivors and reference participants and to identify correlates of LM-Ht and FM-Ht Z-scores in alloHSCT. Results Height Z-scores were significantly lower in alloHSCT survivors ( P < .001) compared with reference participants; body mass index Z-scores did not differ ( P = .13). Survivors had significantly lower mean LM-Ht Z-scores (−0.72; 95% CI, −1.02-−0.42; P < .001) and greater FM-Ht Z-scores (1.10; 95% CI, 0.84-1.39; P < .001) compared with reference participants. LM-Ht Z-score deficits in alloHSCT survivors were larger (−1.26; 95% CI, −1.53-−0.99; P < .001) after adjustment for FM-Ht Z-scores. Endocrinopathies and alloHSCT characteristics were not associated with LM-Ht or FM-Ht Z-scores. Conclusion Survivors of childhood alloHSCT have significant LM deficits and FM excess. Future studies should identify the mechanism and consequences of these abnormalities.