Details

Autor(en) / Beteiligte

• Sinkkonen, Saku T
• Chai, Renjie
• Jan, Taha A
• Hartman, Byron H
• Laske, Roman D
• Gahlen, Felix
• Sinkkonen, Wera
• Cheng, Alan G
• Oshima, Kazuo
• Heller, Stefan

Titel

Intrinsic regenerative potential of murine cochlear supporting cells

Ist Teil von

• Scientific reports, 2011-06, Vol.1 (1), p.26-26, Article 26

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The lack of cochlear regenerative potential is the main cause for the permanence of hearing loss. Albeit quiescent in vivo, dissociated non-sensory cells from the neonatal cochlea proliferate and show ability to generate hair cell-like cells in vitro. Only a few non-sensory cell-derived colonies, however, give rise to hair cell-like cells, suggesting that sensory progenitor cells are a subpopulation of proliferating non-sensory cells. Here we purify from the neonatal mouse cochlea four different non-sensory cell populations by fluorescence-activated cell sorting (FACS). All four populations displayed proliferative potential, but only lesser epithelial ridge and supporting cells robustly gave rise to hair cell marker-positive cells. These results suggest that cochlear supporting cells and cells of the lesser epithelial ridge show robust potential to de-differentiate into prosensory cells that proliferate and undergo differentiation in similar fashion to native prosensory cells of the developing inner ear.