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Photodynamic therapy of cancer: An update
CA: a cancer journal for clinicians, 2011-07, Vol.61 (4), p.250-281
Agostinis, Patrizia
Berg, Kristian
Cengel, Keith
Foster, Thomas
Girotti, Albert
Gollnick, Sandra
Hahn, Stephen
Hamblin, Michael
Juzeniene, Asta
Kessel, David
Korbelik, Mladen
Moan, Johan
Mroz, Pavel
Nowis, Dominika
Piette, Jacques
Wilson, Brian
Golab, Jakub
2011
Details
Autor(en) / Beteiligte
Agostinis, Patrizia
Berg, Kristian
Cengel, Keith
Foster, Thomas
Girotti, Albert
Gollnick, Sandra
Hahn, Stephen
Hamblin, Michael
Juzeniene, Asta
Kessel, David
Korbelik, Mladen
Moan, Johan
Mroz, Pavel
Nowis, Dominika
Piette, Jacques
Wilson, Brian
Golab, Jakub
Titel
Photodynamic therapy of cancer: An update
Ist Teil von
CA: a cancer journal for clinicians, 2011-07, Vol.61 (4), p.250-281
Ort / Verlag
Hoboken: Lippincott Williams
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long‐term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function‐sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment. CA Cancer J Clin 2011. © 2011 American Cancer Society, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0007-9235, 1542-4863
eISSN: 1542-4863
DOI: 10.3322/caac.20114
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3209659
Format
–
Schlagworte
Apoptosis
,
Biochemistry
,
Biochemistry, biophysics & molecular biology
,
Biochimie, biophysique & biologie moléculaire
,
biophysics
,
Cancer therapies
,
Cells
,
Humans
,
Life sciences
,
molecular biology
,
Neoplasms - drug therapy
,
Photochemotherapy - instrumentation
,
Photochemotherapy - methods
,
Photochemotherapy/instrumentation/methods
,
Photosensitizing Agents - therapeutic use
,
Quality of life
,
Sciences du vivant
,
Tumors
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