Details

Autor(en) / Beteiligte

• Vieco, Beatriz
• Martel, Ghyslaine
• Cortes-Mancera, Fabian
• Rios, Wilson Alfredo
• Uribe, Diego
• Carreño, Andrea
• Suarez, Iris
• Navas, Maria-Cristina
• Lozano, Diana
• Jimenez, Carlos
• Gouas, Doriane
• Osorio, German
• Hoyos, Sergio
• Restrepo, Juan-Carlos
• Correa, Gonzalo
• Jaramillo, Sergio
• Lopez, Rocio
• Bravo, Luis Eduardo
• Arbelaez, Maria Patricia
• Scoazec, Jean-Yves
• Abedi-Ardekani, Behnoush
• Santella, Regina M.
• Chemin, Isabelle
• Hainaut, Pierre
• Soussan, Patrick

Titel

Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

Ist Teil von

• Hepatitis Research and Treatment, 2011-01, Vol.2011 (2011), p.56-65

Ort / Verlag

Cairo, Egypt: Hindawi Limiteds

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection.