Details

Autor(en) / Beteiligte

• Pisarska, Margareta D
• Barlow, Gillian
• Kuo, Fang-Ting

Titel

Minireview: Roles of the Forkhead Transcription Factor FOXL2 in Granulosa Cell Biology and Pathology

Ist Teil von

• Endocrinology (Philadelphia), 2011-04, Vol.152 (4), p.1199-1208

Ort / Verlag

Chevy Chase, MD: Endocrine Society

Erscheinungsjahr

2011

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The forkhead transcription factor FOXL2 plays key and diverse roles in female sex determination and ovarian development and in the postnatal ovary and follicle maintenance; its mutations can lead to premature ovarian failure and granulosa cell tumor formation. The forkhead transcription factor (FOXL2) is an essential transcription factor in the ovary. It is important in ovarian development and a key factor in female sex determination. In addition, FOXL2 plays a significant role in the postnatal ovary and follicle maintenance. The diverse transcriptional activities of FOXL2 are likely attributable to posttranslational modifications and binding to other key proteins involved in granulosa cell function. Mutations of FOXL2 lead to disorders of ovarian function ranging from premature follicle depletion and ovarian failure to unregulated granulosa cell proliferation leading to tumor formation. Thus, FOXL2 is a key regulator of granulosa cell function and a master transcription factor in these cells.