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Impenetrable barriers or entry portals? The role of cell-cell adhesion during infection
Ist Teil von
The Journal of cell biology, 2011-10, Vol.195 (3), p.349-358
Ort / Verlag
United States: Rockefeller University Press
Erscheinungsjahr
2011
Quelle
MEDLINE
Beschreibungen/Notizen
Cell-cell adhesion plays a fundamental role in cell polarity and organogenesis. It also contributes to the formation and establishment of physical barriers against microbial infections. However, a large number of pathogens, from viruses to bacteria and parasites, have developed countless strategies to specifically target cell adhesion molecules in order to adhere to and invade epithelial cells, disrupt epithelial integrity, and access deeper tissues for dissemination. The study of all these processes has contributed to the characterization of molecular machineries at the junctions of eukaryotic cells that have been better understood by using pathogens as probes.