Details
- Autor(en) / Beteiligte
- Titel
- iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation
- Ist Teil von
- Cell research, 2011-03, Vol.21 (3), p.550-553
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dear editor, Due to its ethical acceptability and technical feasibil ity, production of induced pluripotent stem （iPS） cells from differentiated somatic cells by exogenous expression of several key transcription factors has given great promise to regenerative medicine and drug discovery . The most commonly used transcription factors in iPS cell induction are Oct4, Sox2, Klf4 and c-Myc .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1001-0602eISSN: 1748-7838DOI: 10.1038/cr.2011.25Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3193427
- Format
- –
- Schlagworte
- Animals, Cellular Reprogramming, Induced Pluripotent Stem Cells - cytology, Induced Pluripotent Stem Cells - metabolism, Intercellular Signaling Peptides and Proteins - genetics, Intercellular Signaling Peptides and Proteins - metabolism, iPS, Letter to the Editor, Mice, MicroRNAs - metabolism, Proto-Oncogene Proteins c-myc - genetics, Proto-Oncogene Proteins c-myc - metabolism, Tetraploidy, Transcription Factors - metabolism, 体细胞, 四倍体, 转录因子