Details

Autor(en) / Beteiligte

• AMANKWAH, Ernest K
• KELEMEN, Linda E
• CHANG-CLAUDE, Jenny
• WANG-GOHRKE, Shan
• NESS, Roberta B
• GOODE, Ellen L
• CUNNINGHAM, Julie M
• FRIDLEY, Brooke L
• VIERKANT, Robert A
• TWOROGER, Shelley S
• WHITTEMORE, Alice S
• MCGUIRE, Valerie
• QINGGANG WANG
• SIEH, Weiva
• GAYTHER, Simon A
• GENTRY-MAHARAJ, Aleksandra
• MENON, Usha
• RAMUS, Susan J
• ROSSING, Mary Anne
• DOHERTY, Jennifer A
• GOODMAN, Marc T
• CARNEY, Michael E
• LURIE, Galina
• HONGLIN SONG
• WILKENS, Lynne R
• KRÜGER KJAER, Susanne
• HØGDALL, Estrid
• CRAMER, Daniel W
• TERRY, Kathryn L
• GARCIA-CLOSAS, Montserrat
• YANG, Hannah
• LISSOWSKA, Jolanta
• ANTON-CULVER, Hoda
• ZIOGAS, Argyrios
• CHENEVIX-TRENCH, Georgia
• SCHILDKRAUT, Joellen M
• BERCHUCK, Andrew
• PHAROAH, Paul D. P
• WEBB, Penelope M
• PEARCE, Celeste L
• WU, Anna H
• PIKE, Malcolm C
• STRAM, Daniel O

Titel

Prostate Cancer Susceptibility Polymorphism rs2660753 is Not Associated with Invasive Ovarian Cancer

Ist Teil von

• Cancer epidemiology, biomarkers & prevention, 2011-05, Vol.20 (5), p.1028-1031

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2011

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, P(trend) = 0.003). We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, P(trend) = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.