Science (American Association for the Advancement of Science), 2011-07, Vol.333 (6041), p.425-425
- Heaphy, Christopher M.
- de Wilde, Roeland F.
- Jiao, Yuchen
- Klein, Alison P.
- Edil, Barish H.
- Shi, Chanjuan
- Bettegowda, Chetan
- Rodriguez, Fausto J.
- Eberhart, Charles G.
- Hebbar, Sachidanand
- Offerhaus, G. Johan
- McLendon, Roger
- Rasheed, B. Ahmed
- He, Yiping
- Yan, Hai
- Bigner, Darell D.
- Oba-Shinjo, Sueli Mieko
- Marie, Suely Kazue Nagahashi
- Riggins, Gregory J.
- Kinzler, Kenneth W.
- Vogelstein, Bert
- Hruban, Ralph H.
- Maitra, Anirban
- Papadopoulos, Nickolas
- Meeker, Alan K.
2011
Details
- Autor(en) / Beteiligte
- Heaphy, Christopher M.
- de Wilde, Roeland F.
- Jiao, Yuchen
- Klein, Alison P.
- Edil, Barish H.
- Shi, Chanjuan
- Bettegowda, Chetan
- Rodriguez, Fausto J.
- Eberhart, Charles G.
- Hebbar, Sachidanand
- Offerhaus, G. Johan
- McLendon, Roger
- Rasheed, B. Ahmed
- He, Yiping
- Yan, Hai
- Bigner, Darell D.
- Oba-Shinjo, Sueli Mieko
- Marie, Suely Kazue Nagahashi
- Riggins, Gregory J.
- Kinzler, Kenneth W.
- Vogelstein, Bert
- Hruban, Ralph H.
- Maitra, Anirban
- Papadopoulos, Nickolas
- Meeker, Alan K.
- Titel
- Altered Telomeres in Tumors with ATRX and DAXX Mutations
- Ist Teil von
- Science (American Association for the Advancement of Science), 2011-07, Vol.333 (6041), p.425-425
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites. Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors. We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative lengthening of telomeres). All of the PanNETs exhibiting these abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein. ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1207313Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3174141
- Format
- –
- Schlagworte
- Adaptor Proteins, Signal Transducing - genetics, Adaptor Proteins, Signal Transducing - metabolism, Biological and medical sciences, BREVIA, Carcinoma, Neuroendocrine - genetics, Carcinoma, Neuroendocrine - pathology, Carcinoma, Neuroendocrine - physiopathology, Cell nucleus, Cell Nucleus - metabolism, Cellular immunity, Central nervous system, Central Nervous System Neoplasms - genetics, Central Nervous System Neoplasms - pathology, Central Nervous System Neoplasms - physiopathology, Chromatin, Chromatin Assembly and Disassembly, Chromosomes, Co-Repressor Proteins, Deoxyribonucleic acid, Diseases of the osteoarticular system, DNA, DNA Helicases - genetics, DNA Helicases - metabolism, Endothelial cells, Gastroenterology. Liver. Pancreas. Abdomen, Genetic mutation, Humans, In Situ Hybridization, Fluorescence, Liver. Biliary tract. Portal circulation. Exocrine pancreas, Medical sciences, Molecular Chaperones, Mutant Proteins - genetics, Mutant Proteins - metabolism, Mutation, Nuclear Proteins - genetics, Nuclear Proteins - metabolism, Pancreatic Neoplasms - genetics, Pancreatic Neoplasms - pathology, Pancreatic Neoplasms - physiopathology, Phenotype, Phenotypes, Proteins, Telomere - physiology, Telomere - ultrastructure, Telomeres, Tumor cell line, Tumor stem cells, Tumors, Tumors of striated muscle and skeleton, X-linked Nuclear Protein