Details

Autor(en) / Beteiligte

• Thomas, Seddon Y
• Scanlon, Seth T
• Griewank, Klaus G
• Constantinides, Michael G
• Savage, Adam K
• Barr, Kenneth A
• Meng, Fanyong
• Luster, Andrew D
• Bendelac, Albert

Titel

PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions

Ist Teil von

• The Journal of experimental medicine, 2011-06, Vol.208 (6), p.1179-1188

Ort / Verlag

United States: The Rockefeller University Press

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern and the mechanism of their intravascular behavior have not been elucidated. Using parabiotic mice, we demonstrated that, despite their intravascular location, most liver NKT cells failed to recirculate. Antibody blocking experiments established that they were retained locally through constitutive LFA-1-intercellular adhesion molecule (ICAM) 1 interactions. This unprecedented lifelong intravascular residence could be induced in conventional CD4 T cells by the sole expression of promyelocytic leukemia zinc finger (PLZF), a transcription factor specifically expressed in the NKT lineage. These findings reveal the unique genetic and biochemical pathway that underlies the innate intravascular surveillance program of NKT cells.