Details

Autor(en) / Beteiligte

• Gibbons, Deena L.
• Abeler-Dörner, Lucie
• Raine, Tim
• Hwang, II-Young
• Jandke, Anett
• Wencker, Melanie
• Deban, Livija
• Rudd, Christopher E.
• Irving, Peter M.
• Kehrl, John H.
• Hayday, Adrian C.

Titel

Regulator of G protein signalling-1 (RGS1) selectively regulates gut T cell trafficking and colitic potential

Ist Teil von

• The Journal of immunology (1950), 2011-07, Vol.187 (5), p.2067-2071

Erscheinungsjahr

2011

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The Regulator of G Protein Signaling 1 [ RGS1 ] gene is associated with celiac disease, multiple sclerosis (MS) and Type I diabetes (T1D), which are all T cell-mediated pathologies. And yet there is no reported analysis of RGS1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood, and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, whereas RGS-1 depletion selectively enhances such chemotaxis in gut T cells, and impairs their colitogenic potential. These findings provide a revised framework in which to view the linkage of RGS1 to inflammatory disease.